Lovastatin (mevinolin, Mevacor), mechanism of action, therapeutic uses and side effects

Lovastatin is effective in treating plasma LDL cholesterol and total cholesterol.

Mechanism Of Action:
Lovastatin competitively inhibit HMG co-enzyme A reductase, a rate limiting step in cholesterol synthesis. Reduce cholesterol synthesis results in compensatory increase in uptake of plasma cholesterol mediated by increase in number of LDL receptors. therefore LDL level in plasma reduces.

Therapeutic Uses:
Lovastatin reduces cholesterol levels in familial and non familial hypercholesterolemias.
Recent studies suggest that statins decreases osteoclast mediated bone resorption and may reduce osteoporosis moreover statins also decrease the incidence of some cancers

Adverse effects:
Myositis, rhabdomyolysis, anxiety, irritability, hepatotoxicity, and elevation in aminotransferasis.