The Bombay Blood Group

Source:  The Bombay Blood Group    Tag:  bombay phenotype
Long time, isnt it folks?
Well, I wont disappoint you! :D

AS is obvious, we only know about 4 Blood Types:-
1)A(+/-)
2)B(+/-)
3)AB(+/-)
4)O(+/-)


Most of us are not aware about another blood group’s existence on this planet.


INTRO

The Bombay blood group is a rare group except in parts of India where a frequency of 1 in 7,600 has been observed. It is know as such because of its origin in Bombay, where it was was first discovered by  Dr. Y.M. Bhende in 1952.  A high level of consanguinity has been observed among the parents of the Bombay phenotype(8). Individuals with the Bombay phenotype fail to express ANY A, B, or H antigen on their red cells or other tissues (8,39)

ORIGINS The discovery of Bombay Blood Group was made more than 50 years ago with a patient who was admitted to KEM Hospital and required blood transfusions.  A sample of blood was sent to the Blood Bank for grouping as is the usual practice.  The red cells grouped like O group and hence O group blood was administered.  The patient developed haemolytic transfusion reaction, and therefore transfusion had to be stopped.
A detailed study of the patients blood revealed a rare genotype (blood group), which was neither ‘A’ nor ‘B’ nor ‘AB’ nor ‘O’.  Blood from a Bombay Blood Group individual only should be transfused to a Bombay Blood Group patient.

MORE ABOUT IT

The cause of this antigenic absence is that the individuals produce no H glycosyl transferase ( FUT1). There is no H enzyme activity detected on the individuals red cells or in their serum. It is now known that the precursor protein from which all blood groups are formed is termed as the ‘H’ Antigen.  The ‘H’ Antigen either translates into ‘A’ Antigen (the blood group is then called ‘A’) or it translates into ‘B’ Antigen (the blood group is then called ‘B’) or it translates into both ‘A’ and ‘B’ Antigens (the blood group is then called ‘AB’) or it remains as ‘H’ (the blood group is called ‘O’).  Earlier the detection of ‘O’ was on the basis of absence of both ‘A’ and ‘B’. In the case of Bombay Blood Group, there was an absence of the ‘H’ Antigen itself.  Therefore ‘A’, ‘B’, ‘AB’ and ‘O’ which are all different manifestations of ‘H’ are all alien for persons with Bombay Blood Group.  The Bombay Blood Group is termed as ‘OH’, which means absence of ‘H’.

OCCURENCES
Although the group is more likely to occur in East Indians, it is a very rare group even here. It is not restricted to East Indians but found in Caucasians, Japanese, etc.
IN MOVIES AND OTHER SIMILAR MEDIA
1)In the 2007 Indian Telugu film Okkadunnadu, both the protagonist Kiran (Gopichand) and the antagonist mafia don Sonu Bhai (Mahesh Manjrekar) are the only two carriers of the Bombay blood type. Kiran's heart is sought after by Sonu Bhai's henchmen for an urgent heart transplant required by Sonu Bhai. 2) In real life, the actor Charlie Chaplin was accused in a paternity suit naming him as the father. Upon investigation it was revealed that the resulting child had the Bombay phenotype, and therefore Mr Chaplin could not be the father because he was found not to be a carrier of the gene. Unfortunately, he was still found guilty and ultimately he provided support to the child. It was said that he lost his case because so very little was known at the time about the workings of genetics, which affected the jury in their determination of the outcome of the case.

IT IS HIGHLY UNLIKELY, THAT A PERSON WITH BOMBAY PHENOTYPE CAN STAY ALIVE IN CASE OF ACCIDENTS OR BLOOD LOSS OF ANY KIND, OR OPERATIONS.

SAD, BUT TRUE. :(